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Manvitha Ponnapati

Manvitha Ponnapati

MIT, MIT Center for Bits and Atoms, MIT Media Lab

Graduate Student

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Manvitha Ponnapati on our team has experience in machine learning, drug discovery and protein engineering. Her work primarily focuses on translating deep learning models for protein engineering to intelligent libraries for experimental screens.

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October 2023

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Generalizable Computational Pipeline for Engineering Ultrastable Variants of Carbonic Anhydrase

By Manvitha Ponnapati

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ScienceReview92
Published on Oct 20, 2023

Carbonic anhydrases (CAs) are ubiquitous metalloenzymes found across eight distinct evolutionary convergent families, typically feature a metal co-factor, with $\alpha$-Carbonic Anhydrase II (PDB ID: 5YUI) showcasing a tetrahedrally coordinated zinc ...

Carbonic anhydrases (CAs) are ubiquitous metalloenzymes found across eight distinct evolutionary convergent families, typically feature a metal co-factor, with $\alpha$-Carbonic Anhydrase II (PDB I...

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